The Molecular Biology
The Molecular Biology
Inborn errors of metabolism (IEMs) are a group of rare genetic disorders that affect the body’s metabolic processes leading to a wide range of symptoms and clinical manifestations. Inborn metabolic disorders are caused by genetic mutations that affect enzymes, transporters,…
A pedigree is a chart or diagram that shows the relationships between members of a family of several generations and can be used to study the inheritance of genetic traits or diseases. A pedigree typically includes information about family members,…
A Punnett square is a graphical representation used in genetics to predict the possible genotypes of offspring resulting from a cross between two parent organisms. It is named after Reginald Punnett, who developed the technique in the early 20th century.…
A reciprocal cross is an experimental technique used in genetics to determine whether the inheritance of a particular trait is affected by the sex of the parent carrying the gene. In a reciprocal cross, two-parent organisms are crossed in two…
Pleiotropy refers to the phenomenon where a single gene has multiple effects on an organism’s phenotype or observable traits. It can affect the phenotypic behavior or characteristics in one or different ways. A pleiotropic effect, thus, refers to the specific…
The principle of complementation is a fundamental concept in genetics that refers to the ability of two different mutations in the same pathway or biological process to restore a wild-type phenotype when they are present together in the same organism.…
What is Alkaptonuria? Alkaptonuria is a rare genetic disorder that affects the metabolism of amino acids – phenylalanine and tyrosine. Due to this, it leads to the buildup of a pigment called homogentisic acid in the body. Accumulation of homogentisic…
Molecular Biology is an interdisciplinary field of science that studies the structure and function of molecules in living organisms. It combines the disciplines of biochemistry, genetics, and cell biology to understand how living organisms work at a molecular level. Molecular…
The P1 (or P) generation, or parental generation, refers to the first set of individuals in a genetic cross that are mated to produce offspring. In a classical Mendelian genetics experiment, the P1 generation is usually comprised of two individuals…
A test cross is a genetic cross between an individual with a dominant phenotype (but an unknown genotype) and a homozygous recessive individual. The is to determine the genotype of the dominant individual. The offspring of a testcross is used…